Toxicity Study on the Effect of Ethanol Extracts of the Root and Leaf of Datura stramonium on the Brain and Non-Prostatic Acid Phosphatase Activity of Wistar rats

Abuse of psychoactive compounds is a growing global challenge, especially in countries with high unemployment rates. Toxicity study was conducted on the effect ethanol extracts root and leaf regularly abused plant Nigeria (Datura stramonium) brain non-prostatic acid phosphatase activity Wistar rats using sixteen (16) average weights 135g that were assigned into four (4) groups A, B, C D each. Groups given same concentration (3.5% chilled Coca-Cola) extracts, both respectively while group (control) administered equal volume Coca-Cola drink. The animals kept separate cages fed normal rat Chaw water provided ad libitum. Rats treatment approximately 3.7mg/Kg body weight extract, control just All sacrificed after day 14th administration. A qualitative phytochemical screening D. stramonium showed it contains alkaloids, tannins, saponins, flavonoids, steroids. Histological examination some levels toxicity (exemplified by shrinkage nerve cells) as well increased serum level non prostatic phosphatase.